pI: 8.6965 |
Length (AA): 191 |
MW (Da): 21765 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 183 | 3lrp (A) | 1 | 181 | 69.00 | 0 | 1 | 1.93132 | -2.02 |
2 | 182 | 1r8q (A) | 2 | 180 | 70.00 | 0 | 1 | 1.86864 | -1.54 |
16 | 179 | 2a5d (A) | 12 | 173 | 65.00 | 0 | 1 | 1.79164 | -2.17 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126696)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G10630 | ADP-ribosylation factor A1F |
Arabidopsis thaliana | AT1G70490 | ARF GTPase family protein |
Arabidopsis thaliana | AT2G47170 | ADP-ribosylation factor 1 |
Arabidopsis thaliana | AT1G23490 | ADP-ribosylation factor 1 |
Arabidopsis thaliana | AT3G62290 | ADP-ribosylation factor A1E |
Arabidopsis thaliana | AT5G14670 | ADP-ribosylation factor A1B |
Babesia bovis | BBOV_III004220 | ADP-ribosylation factor family protein |
Brugia malayi | Bm1_01775 | ADP-ribosylation factor 1 |
Brugia malayi | Bm1_57025 | ADP-ribosylation factor 1 |
Brugia malayi | Bm1_38795 | ADP-ribosylation factor 4 |
Candida albicans | CaO19.13805 | one of two genes similar to S. cerevisiae ADP-ribosylation factors ARF2 (YDL137W) and ARF1 (YDL192W) involved in ER to Golgi tra |
Candida albicans | CaO19.6447 | one of two genes similar to S. cerevisiae ADP-ribosylation factors ARF2 (YDL137W) and ARF1 (YDL192W) involved in ER to Golgi tra |
Candida albicans | CaO19.5964 | one of two genes similar to S. cerevisiae ADP-ribosylation factors ARF2 (YDL137W) and ARF1 (YDL192W) involved in ER to Golgi tra |
Candida albicans | CaO19.13385 | one of two genes similar to S. cerevisiae ADP-ribosylation factors ARF2 (YDL137W) and ARF1 (YDL192W) involved in ER to Golgi tra |
Caenorhabditis elegans | CELE_F57H12.1 | Protein ARF-3 |
Caenorhabditis elegans | CELE_B0336.2 | Protein ARF-1.2 |
Cryptosporidium hominis | Chro.20360 | hypothetical protein |
Cryptosporidium hominis | Chro.30115 | ADP ribosylation factor 1 |
Cryptosporidium parvum | cgd3_860 | ARF1/2 like small GTpase |
Cryptosporidium parvum | cgd2_3410 | ARF1/2 like small GTpase, putative |
Dictyostelium discoideum | DDB_G0280479 | ADP-ribosylation factor-related |
Dictyostelium discoideum | DDB_G0289435 | ADP-ribosylation factor-related |
Dictyostelium discoideum | DDB_G0288015 | ADP-ribosylation factor-related |
Dictyostelium discoideum | DDB_G0280633 | ADP-ribosylation factor-related |
Dictyostelium discoideum | DDB_G0280621 | ADP-ribosylation factor-related |
Dictyostelium discoideum | DDB_G0289173 | ADP-ribosylation factor |
Drosophila melanogaster | Dmel_CG8385 | ADP ribosylation factor at 79F |
Drosophila melanogaster | Dmel_CG11027 | ADP ribosylation factor at 102F |
Echinococcus granulosus | EgrG_001177600 | ADP ribosylation factor 4 |
Echinococcus granulosus | EgrG_000326000 | Arf1 5:ArfA family small GTPase |
Entamoeba histolytica | EHI_137720 | ADP-ribosylation factor 1, putative |
Entamoeba histolytica | EHI_073470 | ADP-ribosylation factor 1, putative |
Echinococcus multilocularis | EmuJ_001177600 | ADP ribosylation factor 4 |
Echinococcus multilocularis | EmuJ_000326000 | Arf1 5:ArfA family small GTPase |
Echinococcus multilocularis | EmuJ_000254750 | |
Echinococcus multilocularis | EmuJ_000674900 | ADP ribosylation factor, arf |
Giardia lamblia | GL50803_7789 | ADP-ribosylation factor |
Homo sapiens | ENSG00000143761 | ADP-ribosylation factor 1 |
Homo sapiens | ENSG00000134287 | ADP-ribosylation factor 3 |
Homo sapiens | ENSG00000168374 | ADP-ribosylation factor 4 |
Homo sapiens | ENSG00000004059 | ADP-ribosylation factor 5 |
Leishmania braziliensis | LbrM.31.3150 | ADP-ribosylation factor, putative |
Leishmania donovani | LdBPK_312890.1 | ADP-ribosylation factor, putative |
Leishmania infantum | LinJ.31.2890 | ADP-ribosylation factor, putative |
Leishmania major | LmjF.31.2790 | ADP-ribosylation factor, putative |
Leishmania mexicana | LmxM.30.2790 | ADP-ribosylation factor, putative |
Loa Loa (eye worm) | LOAG_06291 | ADP-ribosylation factor 1 |
Loa Loa (eye worm) | LOAG_02200 | Arf5 protein |
Mus musculus | ENSMUSG00000051853 | ADP-ribosylation factor 3 |
Mus musculus | ENSMUSG00000020440 | ADP-ribosylation factor 5 |
Mus musculus | ENSMUSG00000021877 | ADP-ribosylation factor 4 |
Mus musculus | ENSMUSG00000062421 | ADP-ribosylation factor 2 |
Mus musculus | ENSMUSG00000048076 | ADP-ribosylation factor 1 |
Neospora caninum | NCLIV_007000 | ADP-ribosylation factor 4, related |
Oryza sativa | 4334545 | Os03g0811900 |
Oryza sativa | 4326208 | Os01g0265100 |
Oryza sativa | 4342746 | Os07g0223400 |
Oryza sativa | 4339157 | Os05g0489600 |
Oryza sativa | 4342745 | Os07g0223100 |
Oryza sativa | 4327591 | Os01g0813400 |
Plasmodium berghei | PBANKA_0505100 | ADP-ribosylation factor, putative |
Plasmodium falciparum | PF3D7_1020900 | ADP-ribosylation factor |
Plasmodium knowlesi | PKNH_0605200 | ADP-ribosylation factor, putative |
Plasmodium vivax | PVX_001905 | ADP-ribosylation factor, putative |
Plasmodium yoelii | PY04572 | ADP-ribosylation factor |
Saccharomyces cerevisiae | YDL137W | Arf family GTPase ARF2 |
Saccharomyces cerevisiae | YDL192W | Arf family GTPase ARF1 |
Schistosoma japonicum | Sjp_0133700 | ko:K07977 Arf/Sar family, other, putative |
Schistosoma japonicum | Sjp_0027490 | ko:K07937 ADP-ribosylation factor 1, putative |
Schistosoma japonicum | Sjp_0008190 | ko:K07939 ADP-ribosylation factor 4, putative |
Schistosoma mansoni | Smp_032180 | ADP-ribosylation factor arf |
Schistosoma mansoni | Smp_088650 | ADP-ribosylation factor arf |
Schmidtea mediterranea | mk4.011209.00 | ADP-ribosylation factor 1-like 1 |
Schmidtea mediterranea | mk4.030408.01 | ADP-ribosylation factor 1-like 2 |
Schmidtea mediterranea | mk4.003484.00 | ADP-ribosylation factor 1-like 2 |
Schmidtea mediterranea | mk4.003168.00 | ADP-ribosylation factor related |
Schmidtea mediterranea | mk4.036520.00 | ADP-ribosylation factor 1-like 2 |
Schmidtea mediterranea | mk4.000572.03 | ADP-ribosylation factor-like protein 14 |
Schmidtea mediterranea | mk4.000572.02 | ADP-ribosylation factor-like protein 14 |
Schmidtea mediterranea | mk4.000572.08 | ADP-ribosylation factor-like protein 14 |
Schmidtea mediterranea | mk4.002212.02 | ADP-ribosylation factor-like protein 14 |
Schmidtea mediterranea | mk4.002212.03 | ADP-ribosylation factor-like protein 14 |
Schmidtea mediterranea | mk4.002212.00 | ADP-ribosylation factor-like protein 14 |
Schmidtea mediterranea | mk4.005672.00 | ADP ribosylation factor-like 4 |
Trypanosoma brucei gambiense | Tbg972.9.8590 | ADP-ribosylation factor, putative |
Trypanosoma brucei gambiense | Tbg972.9.8610 | ADP-ribosylation factor, putative |
Trypanosoma brucei | Tb927.9.13650 | ADP-ribosylation factor, putative |
Trypanosoma brucei | Tb927.9.13740 | ADP-ribosylation factor, putative |
Trypanosoma brucei | Tb927.9.13710 | ADP-ribosylation factor, putative |
Trypanosoma brucei | Tb927.9.13655 | ADP-ribosylation factor, putative |
Trypanosoma congolense | TcIL3000_9_5880 | ADP-ribosylation factor, putative |
Trypanosoma congolense | TcIL3000_9_5890 | ADP-ribosylation factor, putative |
Trypanosoma cruzi | TcCLB.508415.40 | ADP-ribosylation factor 1, putative |
Trypanosoma cruzi | TcCLB.510755.60 | ADP-ribosylation factor 1, putative |
Trypanosoma cruzi | TcCLB.508415.50 | ADP-ribosylation factor 1, putative |
Trypanosoma cruzi | TcCLB.510755.50 | ADP-ribosylation factor 1, putative |
Toxoplasma gondii | TGME49_276140 | ADP ribosylation factor ARF1 |
Theileria parva | TP02_0245 | ADP-ribosylation factor, putative |
Trichomonas vaginalis | TVAG_204680 | ADP-ribosylation factor, arf, putative |
Trichomonas vaginalis | TVAG_132550 | ADP-ribosylation factor, arf, putative |
Trichomonas vaginalis | TVAG_255170 | ADP-ribosylation factor, arf, putative |
Trichomonas vaginalis | TVAG_145360 | ADP-ribosylation factor, arf, putative |
Trichomonas vaginalis | TVAG_294070 | ADP-ribosylation factor, arf, putative |
Trichomonas vaginalis | TVAG_148040 | ADP-ribosylation factor, arf, putative |
Trichomonas vaginalis | TVAG_301220 | ADP-ribosylation factor, arf, putative |
Trichomonas vaginalis | TVAG_064150 | ADP-ribosylation factor, arf, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_B0336.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0336.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_B0336.2 | Caenorhabditis elegans | sterile | wormbase |
CELE_F57H12.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F57H12.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F57H12.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F57H12.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F57H12.1 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0505100 | Plasmodium berghei | Essential | plasmo |
TGME49_276140 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ADP-ribosylation factor 1 | Compounds | References |